High-Resolution Evolutionary Analysis of Within-Host Hepatitis C Virus Infection

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Absence of Hepatitis C Virus Infection Among Patients with Hepatitis B virus in Mashhad, Iran

Background and Aims: Many studies have provided evidence for the role of hepatitis B and C viruses in the development of liver cancer. Although the routine treatment is available for both conditions, no definite guideline is available to treat patients dually infected with HBV and HCV. This study was performed to determine the frequency of HBV/HCV-coinfection in Mashhad, North-East of Iran. Mat...

متن کامل

Spatiotemporal Analysis of Hepatitis C Virus Infection

Hepatitis C virus (HCV) entry, translation, replication, and assembly occur with defined kinetics in distinct subcellular compartments. It is unclear how HCV spatially and temporally regulates these events within the host cell to coordinate its infection. We have developed a single molecule RNA detection assay that facilitates the simultaneous visualization of HCV (+) and (-) RNA strands at the...

متن کامل

Host neutralizing responses and pathogenesis of hepatitis C virus infection.

The recent development of novel model systems for the early steps of hepatitis C virus (HCV) infection has rapidly advanced our knowledge of antibody-mediated virus neutralization in patients with acute and chronic hepatitis C. This review summarizes our current understanding of host neutralizing responses during the course of HCV infection. It focuses on recent studies in HCV-infected patients...

متن کامل

Hepatitis C virus infection and genotypes in blood donors

Abstract: Genotyping of the hepatitis C virus (HCV) is important for designing therapeutic strategies and regional specific diagnostic assays. The aim of this study was to identify the HCV genotypes in HCV infected blood donors. This is the first report on HCV genotypes in blood donors in Iran. In this cross-sectional study, 103 blood donors with hepatitis C were investigated for HCV genotype...

متن کامل

A New Evolutionary Model for Hepatitis C Virus Chronic Infection

Hepatitis C virus (HCV) infects an estimated 3% of humanity [1] and is a leading global cause of liver disease and liver cancer [2]. Intervention is currently limited by the lack of a vaccine and of universally successful drug treatments. Although several next-generation drugs (e.g., direct-acting protease-inhibitors) are already improving outcomes, a number of factors will affect overall treat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The Journal of Infectious Diseases

سال: 2019

ISSN: 0022-1899,1537-6613

DOI: 10.1093/infdis/jiy747